An inhibitor of GLS1
货号:ajcx22574
CAS:1832646-52-2
分子式:C19H21N7O2S
分子量：411.5
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC₅₀= 0.021 μM).¹It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cellsin vitro(GI₅₀= 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.

1.Finlay, M.R.V., Anderton, M., Bailey, A., et al.Discovery of a thiadiazole-pyridazine-based allosteric glutaminase 1 inhibitor series that demonstrates oral bioavailability and activity in tumor xenograft modelsJ. Med. Chem.62(14)6540-6560(2019)