C-170

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C-170

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	288.3

包装与价格：

包装	价格(元)
10mg	询价
25mg	询价
50mg	询价
100mg	询价

A STING inhibitor
货号:ajcx21894
CAS:346691-38-1
分子式:C15H16N2O4
分子量：288.3
溶解度:DMSO: Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C-170 is an inhibitor of stimulator of interferon genes (STING).^1,2It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.¹It selectively reduces human and mouse STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.02 to 2 µM.

1.Haag, S.M., Gulen, M.F., Reymond, L., et al.Targeting STING with covalent small-molecule inhibitorsNature559(7713)269-273(2018) 2.Zhang, H., You, Q.-D., and Xu, X.-L.Targeting stimulator of interferon genes (STING): A medicinal chemistry perspectiveJ. Med. Chem.63(8)3785-3816(2019)