An internal standard for the quantification of acamprosate
货号:ajcx21588
CAS:1225580-94-8
分子式:C5H7D3NO4S.1/2Ca
分子量：203.3
溶解度:Water: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Acamprosate-d₃is intended for use as an internal standard for the quantification of acamprosate by GC- or LC-MS. Acamprosate is an acetylated derivative of the GABA analog homotaurine .¹Despite its structural similarity to GABA, acamprosate does not act at GABA_Areceptors but does decrease paired-pulse inhibition of GABA_Ainhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 µM, indicating that it may inhibit GABA_Bautoreceptor-mediated inhibition of GABA release.^2,3,4It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors.⁴Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline . Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.

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