A byproduct in solid-phase peptide synthesis
货号:ajcx20944
CAS:404887-22-5
分子式:C4H6N2O2
分子量：114.1
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(R)-Aspartimide is a byproduct formed during solid-phase peptide synthesis (SPPS) of aspartic acid-containing peptides.¹Aspartimide is formed by cyclization of aspartic acid during Fmoc removal or peptide coupling.²

1.Ruczyński, J., Lewandowska, B., Mucha, P., et al.Problem of aspartimide formation in Fmoc-based solid-phase peptide synthesis using Dmab group to protect side chain of aspartic acidJ. Pept. Sci.14(3)335-341(2008) 2.Neumann, K., Farnung, J., Baldauf, S., et al.Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groupsNat. Commun.11(1)982(2020)