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Sotalol-d6(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sotalol-d6(hydrochloride)图片
包装:1mg
规格:98%
市场价:3541元
分子量:314.9

An internal standard for the quantification of sotalol
货号:ajcx20172
CAS:1246820-85-8
分子式:C12H14D6N2O3S.HCl
分子量:314.9
溶解度:DMSO: soluble,Methanol: soluble,Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Sotalol-d6 is intended for use as an internal standard for the quantification of sotalol by GC- or LC-MS. Sotalol is a non-selective antagonist of β-adrenergic receptors (ARs) that inhibits β1-, β2-, and β3-ARs with IC50 values ranging from 0.1 to 8.9 μM.1,2,3 Through its effects on β2-ARs, sotalol also blocks outward potassium currents in myocardium, exhibiting Class III antiarrhythmic actions.4,5


|1. Tsuchihashi, H., Nakashima, Y., Kinami, J., et al. Characteristics of 125I-iodocyanopindolol binding to β-adrenergic and serotonin-1B receptors of rat brain: Selectivity of β-adrenergic agents. Jpn. J. Pharmacol. 52(2), 195-200 (1990).|2. Lis, R., Morgan, T.K., Jr., Marisca, A.J., et al. Synthesis of novel (aryloxy) propanolamines and related compounds possessing both class II and class III antiarrhythmic activity. J. Med. Chem 33(10), 2883-2891 (1990).|3. Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005).|4. Campbell, T.J., and Williams, K.M. Therapeutic drug monitoring: Antiarrhythmic drugs. Br. J. Clin. Pharmacol. 52, 307-319 (1998).|5. Khairy, P., and Nattel, S. New insights into the mechanisms and management of atrial fibrillation. Can. Med. Assoc. .J. 167(9), 1012-1020 (2002).

 
 
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