SNIPER(ER)-110 由 cIAP1 配体和雌激素配体，通过 linker 连接组成。SNIPER(ER)-110 诱导雌激素受体 (estrogen receptor; ER) 蛋白降解，处理 4 小时和 48 小时后，DC50 分别为<3 nm 和 7.7 nm。
货号:ajcx14130
CAS:N/A
分子式:C66H83N5O11
分子量：1122.39
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of<3 nM and 7.7 nM after 4 h and 48 h, respectively[1].

[1]. Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293(18):6776-6790.