7-BIA 是一种受体型蛋白酪氨酸磷酸酶 D (PTPRD) 抑制剂，IC50 值约为 1-3 μM。
货号:ajcx39494
CAS:1313403-49-4
分子式:C15H18O6
分子量：294.3
溶解度:DMSO : 125 mg/mL (424.74 mM; Need ultrasonic)|Ethanol : 50 mg/mL (169.89 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1].

7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC50 values of ~1-3 μM and 40 μM, respectively[1].

7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice[1].

[1]. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosinephosphatase D (PTPRD) and by a novel PTPRD antagonist. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11597-11602.