FTX-6058 hydrochloride 是一种有效的，具有口服活性的胚胎外胚层发育 (EED) 抑制剂。FTX-6058 hydrochloride 可以在细胞和鼠模型中诱导 HbF 蛋白表达。FTX-6058 hydrochloride 可用于特定血红蛋白病的研究，包括镰状细胞病和 β-地中海贫血。
货号:ajcx35894
CAS:2490676-19-0
分子式:C22H19ClFN5O2
分子量：439.87
溶解度:DMSO : 125 mg/mL (284.17 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 hydrochloride can induce HbF protein expression in cell and murine models. FTX-6058 hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia[1][2].

FTX-6058 hydrochloride inhibits PRC2 via binding to EED, which induces robust HbF protein expression in both cell and murine models[2].

[1]. Boerner LK. Virtual meeting delivers first time drug structures. April 12, 2021.