G140 是一种有效和选择性的环状 GMP-AMP 合酶 (cGAS) 的抑制剂，对 h-cGAS 和 m-cGAS 的 IC50 值分别为 14.0 nM 和 442 nM。G140 具有抗炎活性。
货号:ajcx34172
CAS:2369751-07-3
分子式:C17H16Cl2N4O2
分子量：379.24
溶解度:DMSO : 250 mg/mL (659.21 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].

G140 (0.1-100 µM; 4 h) inhibits h-cGAS in a dose-dependent manner with IC50s of 1.70 and 0.86 µM in human THP1 and primary macrophages, respectively[1].G140 (0.1-100 µM; 24 h) inhibits cells viability with a LD50 of >100 µM in THP1 cells[1].

[1]. Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261.