RMC-0331 (RM-023) 是一种高效、选择性和口服生物利用度 SOS1 抑制剂。RMC-0331 是一种体内工具化合物，通过破坏 RAS-SOS1 相互作用阻断 RAS 激活。
货号:ajcx33832
CAS:2488788-52-7
分子式:C22H25ClF3N5O3
分子量：499.91
溶解度:DMSO : 125 mg/mL (250.05 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].

RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro[1].

RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models[1].

[1]. Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction.