MCU-i4阻断IP3依赖的线粒体Ca2+的摄取，维持靶点的"管家"角色。
货号:ajcx32458
CAS:371924-24-2
分子式:C23H27N3O2
分子量：377.48
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2].

MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1].MCU-i4 exerted a negative effect on δψ. MCU-i4 has no effect on cell viability[1]. Cell Differentiation Assay[1] Cell Line: Growing medium of 90% confluent C2C12 myoblasts.

[1]. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. [2]. Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645.