ML604440是一种有效的，特异性和细胞可渗透的蛋白酶体β1i(LMP2)亚基抑制剂。ML604440破坏MHCI类细胞表面表达，IL-6分泌以及naÏveThelper向17Thelper细胞的分化。ML604440改善实验性结肠炎和EAE疾病。
货号:ajcx31086
CAS:1140517-08-3
分子式:C17H24BF3N2O4
分子量：388.19
溶解度:DMSO: 100 mg/mL (257.61 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1].ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naÏve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].

[1]. de Bruin G, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57(14):6197-209 [2]. Basler M, et al. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. 2018 Dec;19(12). pii: e46512.