Malachitegreenoxalate是一种三苯基甲烷染料，可用于检测酶促反应中磷酸盐的释放。Malachitegreenoxalate也是一种有效和选择性的IKBKE抑制剂，同时抑制其下游靶标，如IκBα，p65和IRF3。Malachitegreenoxalate在体外和体内均表现出抗肿瘤活性。
货号:ajcx30980
CAS:2437-29-8
分子式:C23H25N2.1/2C2H2O4.C2HO4
分子量：463.5
溶解度:DMSO: 25 mg/mL (53.94 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3].

[1]. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13. [2]. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91. [3]. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.