Biotin-PEG4-amine 是一种生物素标记的 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
货号:ajcx29176
CAS:663171-32-2
分子式:C20H38N4O6S
分子量：462.6
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Biotin-PEG4-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.