An inhibitor of NLRP3 inflammasome activation
货号:ajcx28484
CAS:2768759-64-2
分子式:C16H19N2O5S ? Na
分子量：374.4
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Inflammasome inhibitor 4b is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation.¹It inhibits ATP-induced IL-1β release by 98.3% in LPS-primed mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 1 µM. Inflammasome inhibitor 4b (3 and 10 mg/kg) decreases paw swelling and mechanical hyperalgesia in a mouse model of gout induced by monosodium urate crystals.

1.Narros-FernÁndez, P., Chioua, M., Petcu, S.A., et al.Synthesis and pharmacological evaluation of new N-sulfonylureas as NLRP3 inflammasome inhibitors: Identification of a hit compound to treat goutJ. Med. Chem.65(8)6250-6260(2022)