LP 922761 是一种有效的、选择性的和口服活性的接头蛋白 2 相关激酶 1 (AAK1) 抑制剂，在酶和细胞试验中的 IC50 分别为 4.8 nM 和 7.6 nM。
货号:ajcx27476
CAS:1454808-95-7
分子式:C21H26N6O3
分子量：410.47
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.

Kostich et al (2016) Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J.Pharmacol.Exp.Ther. 358 371 PMID:27411717