Photoswitchable TRPV1 channel blocker
货号:ajcx27056
CAS:1459809-09-6
分子式:C26H25F3N4O2S
分子量：514.56
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Photoswitchable TRPV1 channel blocker (IC50 = 3.1 μM). Acts as an antagonist in trans conformation during voltage gated activation. Also acts as an antagonist in the cis formation during capsaicin-induced TRPV1 currents. Switches conformation from cis to trans at 440 nm and trans to cis at 360 nm. Allows photoswitchable antagonist and an agonist to be applied at the same time.

Stein et al (2013) Optical control of TRPV1 channels. Angew.Chem.Int.Ed.Engl. 52 9845 PMID:23873837