Menin-MLL interaction inhibitor
货号:ajcx26870
CAS:N/A
分子式:C18H25N5S2.2HCl
分子量：448.48
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Menin-MLL interaction inhibitor; binds menin (IC50 = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.

Grembecka et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat.Chem.Biol. 8 277 PMID:22286128 |Phillips et al (2019) Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc.Natl.Acad.Sci.U.S.A. 116 7957 PMID:30923116