YIL 781 hydrochloride 是一种有效且具有口服活性的 ghrelin receptor (GHSR) 拮抗剂。
货号:ajcx26824
CAS:1640226-17-0
分子式:C24H28FN3O2.HCl
分子量：445.96
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). Displays no significant affinity for the motilin receptor (Ki = 6 μM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo.

Esler et al (2007) Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148 5175 PMID:17656463 |Moran and Dailey (2009) Gut peptides: targets for antiobesity drug development• Endocrinology 150 2526 PMID:19372201