7-Ethoxy-4-(trifluoromethyl)coumarin 是细胞色素 P450 超家族各种酶的荧光底物
货号:ajcx25602
CAS:115453-82-2
分子式:C12H9F3O3
分子量：258.2
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：
现货Background:
7-Ethoxy-5-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs).1Upon O-deethylation by CYPs, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP activity. HFC displays excitation/emission maxima of 410/510 nm, respectively.
1.Buters, J.T.M., Schiller, C.D., and Chou, R.C.A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation of 7-ethoxy-4-trifluoromethylcoumarinBiochem. Pharmacol.46(9)1577-1584(1993)
