C27H24D5N3O6•HCl
货号:ajcx24050
CAS:N/A
分子式:C27H24D5N3O6•HCl
分子量：533
溶解度:DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Barnidipine-d5 (hydrochloride) is intended for use as an internal standard for the quantification of barnidipine by GC- or LC-MS. Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery.¹It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day.²Formulations containing barnidipine have been used in the treatment of hypertension.

1.Nakayama, K., Kashiwabara, T., Yamada, S., et al.Assessment in pig coronary artery of long-lasting and potent calcium antagonistic actions of the novel dihydropyridine derivative mepirodipine hydrochlorideArzneimittelforschung39(1)50-55(1989) 2.Kawashima, K., Toda, H., Oohata, H., et al.Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive ratsGen. Pharmacol.22(2)263-266(1991)