AC-262536 是一种选择性和非甾体雄激素受体调节剂 (SARM)，具有有益的合成代谢作用。
货号:ajcx21586
CAS:870888-46-3
分子式:C18H18N2O
分子量：278.4
溶解度:DMSO: Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AC-262536 is a selective androgen receptor modulator (SARM; K_i= 5.01 nM).¹It is also a partial agonist of the androgen receptor (EC₅₀= 1.58 nM in a luciferase assay). AC-262536 is selective for the androgen receptor over a panel of 47 additional human nuclear receptors at 10 µM. It inhibits dihydroxytestosterone-induced proliferation of LNCaP prostate cancer cells when used at concentrations of 0.1 and 1 µM. AC-262536 (3, 10, and 30 mg/kg) reduces plasma luteinizing hormone levels and increases levator ani muscle weight, a marker of anabolic activity, in castrated rats. It exhibits smaller increases in prostate gland and seminal vesicle weight, markers of androgenic activity, compared with testosterone in the same model.

1.Piu, F., Gardell, L.R., Son, T., et al.Pharmacological characterization of AC-262536, a novel selective androgen receptor modulatorJ. Steroid Biochem. Mol. Biol.109(1-2)129-137(2008)