CINPA1 是一种有效且特异性的组成型雄甾烷受体 (CAR) 抑制剂，不会激活孕烷 X 受体 (PXR)。
货号:ajcx20176
CAS:102636-74-8
分子式:C23H29N3O3
分子量：395.5
溶解度:DMSO: 100 mM,Ethanol: 100 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CINPA1 is a constitutive androstane receptor (CAR) antagonist (IC50 = 70 nM in a reporter assay).1 It is selective for CAR over the nuclear receptors GR, FXR, LXRα, LXRβ, PPARγ, RXRα, and RXRβ at 18 μM, but also antagonizes the human pregnane X receptor (PXR; IC50 = 6.6 μM). CINPA1 (0.3-5 μM) inhibits CAR transactivation of CYP2B6 induced by CITCO in primary human hepatocytes.

|1. Cherian, M.T., Lin, W., Wu, J., et al. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol. Pharmacol. 87(5), 878-889 (2015).