硝酸异山梨酯 (ISDN) 是一种 NO 供体，可防止心肌梗死 (MI) 后 LV 重塑和心脏功能退化。
货号:ajcx19486
CAS:87-33-2
分子式:C6H8N2O8
分子量：236.1
溶解度:Chloroform: Slightly Soluble,Methanol: Slightly Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.1 It induces vasodilation with IC50 values of 0.56 and 1.82 μM for isolated precontracted rabbit femoral vein and artery, respectively.2 Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model.3 It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range.4 Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.

参考文献
1. Ahlner, J., Andersson, R.G., Torfgard, K., et al. Organic nitrate esters: Clinical use and mechanisms of actions. Pharmacol. Rev. 43(3), 351-423 (1991).
2. Toyoda, J., Hisayama, T., and Takayanagi, I. Nitro compounds (isosorbide dinitrate, 5-isosorbide mononitrate and glyceryl trinitrate) on the femoral vein and femoral artery. Gen. Pharmacol. 17(1), 89-91 (1986).
3. Jordan, B.F., Misson, P., Demeure, R., et al. Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: Monitoring by EPR and MRI. Int. J. Radiat. Oncol. Biol. Phys. 48(2), 565-570 (2000).
4. De Caterina, R., Giannessi, D., Bernini, W., et al. Organic nitrates: Direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates. Thromb. Haemost. 59(2), 207-211 (1988).