EB-3D 是有效的选择性胆碱激酶 α (ChoKα) 抑制剂，对 ChoKα1 的 IC50 值为 1 μM。EB-3D 诱导白血病 T 细胞中 AMPK-mTOR 通路解除和凋亡 (apoptosis)。EB-3D 在一组T-白血病细胞系中显示出强大的抗增殖活性。具有抗癌活性。
货号:ajcx16516
CAS:1839150-63-8
分子式:C30H36Br2N4O2
分子量：644.44
溶解度:DMSO: 50 mg/mL (77.59 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity[1][2][3].

[1]. Mariotto E, et al. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. Biochem Pharmacol. 2018 Sep;155:213-223. [2]. Sola-Leyva A, et al. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells. Sci Rep. 2019 Mar 25;9(1):5109. [3]. Schiaffino-Ortega S, et al. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).