Fluticasone furoate 是一种局部，鼻内，增强亲和力的合成的三氟皮质类固醇，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎和抗哮喘活性，并且全身暴露率低。Fluticasone furoate 可用于过敏性鼻炎的研究。
货号:ajcx16220
CAS:397864-44-7
分子式:C27H29F3O6S
分子量：538.58
溶解度:DMSO: 250 mg/mL (464.18 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment[1][2].

[1]. Giavina-Bianchi P, et al. Fluticasone furoate nasal spray in the treatment of allergic rhinitis. Ther Clin Risk Manag. 2008 Apr;4(2):465-72. [2]. Alizadeh Z, et al. Asthma phenotypes and T-bet protein expression in cells treated with Fluticasone Furoate/Vilanterol. Pulm Pharmacol Ther. 2020 Feb;60:101886.