sAJM589 是一种 Myc 抑制剂，能干扰 Myc- max 异二聚体的形成，其 IC50 值为 1.8 μM。
货号:ajcx15474
CAS:2089-82-9
分子式:C16H10N2O
分子量：246.26
溶解度:DMSO: 5 mg/mL (20.30 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC50 of 1.8 μM[1].

sAJM589 potently disrupts the Myc-Max heterodimer to reduce Myc protein levels in a dose dependent manner, with an IC50 of 1.8 μM[1].sAJM589 suppresses cellular proliferation in diverse Myc-dependent cancer cell lines and anchorage independent growth of Raji cells[1].

[1]. Choi SH, et al. Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule. ACS Chem Biol. 2017 Nov 17;12(11):2715-2719.