AZD7624是一种可吸入的p38抑制剂，具有高效的抗炎活性。
货号:ajcx12702
CAS:1095004-78-6
分子式:C27H30FN5O3
分子量：491.56
溶解度:DMSO: 250 mg/mL (508.58 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50u of 8.4, 8.7, and 9.0[1].

[1]. Pehrson R, et al. AZD7624, an Inhaled p38 Inhibitor, Demonstrates Local Lung Inhibition of LPS-Induced TNFα with Minimal Systemic Exposure. J Pharmacol Exp Ther. 2018 Jun;365(3):567-572.