GNE-502 是一种口服有效的雌激素受体 (ER) 降解剂。GNE-502 可用于乳腺癌研究。
货号:ajcx39876
CAS:1953134-16-1
分子式:C25H30FN3O3S
分子量：471.59
溶解度:DMSO : 100 mg/mL (212.05 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1].

GNE-502 (10 and 100 mg/kg; p.o.) possesses sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model[1].GNE-502 shows dose dependent tumor growth inhibition at 10 mg/kg and 30 mg/kg, with tumor stasis at 100 mg/kg[1].

[1]. Zbieg JR, et al. Discovery of GNE-502 as an Orally Bioavailable and Potent Degrader for Estrogen Receptor Positive Breast Cancer [published online ahead of print, 2021 Aug 20]. Bioorg Med Chem Lett. 2021;128335.