AXKO-0046 是一种吲哚衍生物和小分子 LDHB选择性抑制剂。
货号:ajcx39692
CAS:N/A
分子式:C25H33N3
分子量：375.55
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.

AXKO-0046 has selectivity and highly potent LDHB inhibitory activity with an value EC50 of 42 nM. AXKO-0046 bounds to the potential allosteric site away from the LDHB catalytic active site. AXKO-0046 can be used to validate LDHB associated pathways in cancer metabolism[1].

[1]. Sachio Shibata, et al. Identification of the first highly selective inhibitor of human lactate dehydrogenase B. Sci Rep. 2021 Nov 1;11(1):21353.