ARS-1323-alkyne，一种 switch-II pocket (S-IIP) 抑制剂，是活体细胞中 KRASG12C 核苷酸状态的构象特异性化学报告者。
货号:ajcx39662
CAS:2436544-27-1
分子式:C28H27ClF2N6O3
分子量：569
溶解度:DMSO : 35.71 mg/mL (62.76 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：
现货Background:
ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells[1].
[1]. Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450.
Protocol:
