STAT5-IN-2 是 STAT5 的抑制剂，在 K562 和 KU812 细胞中的 EC50 分别为 9 μM和 5 μM，在文献 1 的名称是 17f。STAT5-IN-2 具有高效的抗白血病活性。
货号:ajcx39398
CAS:2111834-61-6
分子式:C26H27N3O
分子量：397.51
溶解度:DMSO : 100 mg/mL (251.57 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect[1].

STAT5-IN-2 has EC50 values of 9 μM and 5 μM in K562 and KU812 cells, respectively[1].STAT5-IN-2 (100 nM-50 µM; 48 hours) has EC50 values of 2.6 µM and 3.5 µM in KG1a and MV-4-11 cells, respectively[1].STAT5-IN-2 (10 µM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells)[1]. STAT5-IN-2 (10 µM; 24 hours) blocks phosphorylation of STAT5[1].

[1]. Ludovic Juen, et al. New Inhibitor Targeting Signal Transducer and Activator of Transcription 5 (STAT5) Signaling in Myeloid Leukemias. J Med Chem. 2017 Jul 27;60(14):6119-6136.

Protocol:

STAT5 9μM(EC50,inK562cells)

STAT5 5μM(EC50,inKU812cells)