KCC009 是转谷氨酰胺酶 2 的抑制剂，可诱导 p53 途径依赖的放疗敏感性。
货号:ajcx37796
CAS:744198-19-4
分子式:C21H22BrN3O5
分子量：476.32
溶解度:DMSO : 250 mg/mL (524.86 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

KCC009, a transglutaminase 2 (TG2) inhibitor, induces p53-independent radiosensitization[1][2].

The inhibition rates were 15.33±1.46 (%) for H1299/WT-p53 cells, and 14.31±1.90 (%) for H1299/M175H-p53 cells when cells were treated with KCC009 at concentration of 3.91 uM[1].

[1]. Sheng Huaying, et al. Transglutaminase 2 Inhibitor KCC009 Induces p53-Independent Radiosensitization in Lung Adenocarcinoma Cells. Med Sci Monit. 2016 Dec 21;22:5041-5048.
[2]. L Yuan, et al. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene