Boc-NH-C4-Br 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。
货号:ajcx37118
CAS:164365-88-2
分子式:C9H18BrNO2
分子量：252.15
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Hu R, et, al. Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor. Eur J Med Chem. 2022 Jan 5;227:113922.