BIO-013077-01 是一种吡唑类的 TGF-β 抑制剂。
货号:ajcx34570
CAS:746667-48-1
分子式:C17H13N5
分子量：287.32
溶解度:DMSO : 100 mg/mL (348.04 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BIO-013077-01 is a pyrazole TGF-β inhibitor[1].

A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies[1].

[1]. Jin CH, et al. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Eur J Med Chem. 2011 Sep;46(9):3917-25.