BGC-20-1531 (PGN 1531) free base 是一种有效的选择性前列腺素 EP4 受体拮抗剂， pKB 值为 7.6。BGC-20-1531 free base 具有研究偏头痛的潜力。
货号:ajcx34568
CAS:736183-35-0
分子式:C26H24N2O6S
分子量：492.54
溶解度:DMSO : 250 mg/mL (507.57 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKB of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache[1].

BGC-20-1531 free base competitively antagonized PGE2-induced vasodilatation of human middle cerebral (pKb=7.8) and meningeal (pKb=7.6) arteries, but had no effect on responses induced by PGE2 on coronary, pulmonary or renal arteries[1].

BGC-20-1531 free base (1-10 mg/kg; i.v.) causes a dose-dependent antagonism of the PGE2-induced increase in canine carotid blood flow[1].

[1]. Maubach KA, et al. BGC20-1531, a novel, potent and selective prostanoid EP receptor antagonist: a putative new treatment for migraine headache. Br J Pharmacol. 2009;156(2):316-327.