653-47 hydrochloride 是一种增强剂，能显著增强 666-15 的 cAMP 反应元件结合蛋白 (CREB) 抑制活性。653-47 hydrochloride 也是一种很弱的抑制剂，其 IC50 为 26.3 μM。
货号:ajcx33140
CAS:1224567-46-7
分子式:C20H20Cl2N2O3
分子量：407.29
溶解度:DMSO : 250 mg/mL (613.81 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].

653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].

[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.