Oxatomide是一种有效的具有口服活性的双重H1组胺受体(H1-histaminereceptor)和P2X7受体拮抗剂，具有抗组胺和抗过敏活性。Oxatomide几乎完全阻断人P2X7受体中ATP诱导的电流(IC50为0.95μM)。Oxatomide可抑制ATP诱导的Ca2+内流，IC50值为0.43μM，并且还抑制5-羟色胺(serotonin)。
货号:ajcx31704
CAS:60607-34-3
分子式:C27H30N4O
分子量：426.55
溶解度:DMSO: 250 mg/mL (586.10 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin[1][2].

[1]. Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51. [2]. K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409.