GRP-60367 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	389.92

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

GRP-60367hydrochloride是种首创的小分子狂犬病病毒(RABV)进入抑制剂，对某些RABV株具有纳摩尔作用效果。GRP-60367hydrochloride特异性靶向RABVG蛋白。
货号:ajcx30738
CAS:N/A
分子式:C21H28ClN3O2
分子量：389.92
溶解度:DMSO: 250 mg/mL (641.16 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein[1].

GRP-60367 (0.1 nM-1000 μM) confirms specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC50s ranging from 2 to 52 nM on different host cell lines[1]. Cell Viability Assay[1] Cell Line: BEAS-2B, 293T, or Hep-2 cell lines

[1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.