Solanidine 是一种胆甾烷生物碱，从几种马铃薯物种中分离出来，包括 Solanum demissum、Solanum acaule 和 Solanum tuberosum。茄尼定能抑制增殖并表现出明显的抗肿瘤作用。
货号:ajcx28334
CAS:80-78-4
分子式:C27H43NO
分子量：397.6
溶解度:DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Solanidine is a steroidal glycoalkaloid metabolite that has been found in potato (S. tuberosum) and has anticancer and teratogenic activities.^1,2,3It inhibits the growth of HT-29 colon and HepG2 liver cancer cells by 80.9 and 82.2%, respectively, when used at a concentration of 100 μg/ml.²Solanidine (176 mg/kg) is teratogenic to hamster embryos when administered to pregnant dams on day eight of gestation.³

1.Nikolic, N.C., and Stankovic, M.Z.Solanidine hydrolytic extraction and separation from the potato (Solanum tuberosum L.) vines by using solid-liquid-liquid systemsJ. Agric. Food Chem.51(7)1845-1849(2003) 2.Lee, K.-R., Kozukue, N., Han, J.-S., et al.Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cellsJ. Agric. Food Chem.52(10)2832-2839(2004) 3.Gaffield, W., and Keeler, R.F.Implication of C-5, C-6 unsaturation as a key structural factor in steroidal alkaloid-induced mammalian teratogenesisExperientia49(10)922-924(1993)