K-(D-1-Nal)-FwLL-NH2 是一种高亲和力、有效的反向 ghrelin 受体激动剂 (EC50=3.4 nM, Ki=4.9 nM)。
货号:ajcx27254
CAS:1394288-22-2
分子式:C51H67N9O6
分子量：902.13
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

High affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

Els et al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437 PMID:22920150 |M'Kadmi et al (2015) Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 290 27021 PMID:26363071