Quin C1 是一种高度特异性和有效的甲酰肽受体 2 (FPR2/ALX) 激动剂。
货号:ajcx27134
CAS:786706-21-6
分子式:C26H27N3O4
分子量：445.51
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.

Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976 PMID:17652444 |Corminboeuf et al (2014) FPR2/ALXR agonists and the resolution of inflammation. J.Med.Chem. 58 537 PMID:25365541