Irreversible protein disulfide isomerase (PDI) inhibitor
货号:ajcx26926
CAS:1401089-31-3
分子式:C21H22N2O6S
分子量：430.47
溶解度:DMSO: 100 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.

Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577 PMID:24070012 |Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348 PMID:22988091