QO 58 是 K(v)7 通道的有效调节剂。
货号:ajcx26914
CAS:1259536-62-3
分子式:C18H8Cl2F4N4O
分子量：443.18
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.

Zhang et al (2013) Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br.J.Pharmacol. 168 1030 PMID:23013484 |Qi et al (2011) Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur.J.Med.Chem. 46 934 PMID:21296466