NAV 26 (compound 26) 是一种选择性电压门控钠通道 Nav1.7 阻滞剂，IC50 为 0.37 μM。
货号:ajcx26866
CAS:1198160-14-3
分子式:C22H21F3N2O4
分子量：434.41
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Selective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.

Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866 PMID:22770500