Potent and noncompetitive NMDA antagonist
货号:ajcx26846
CAS:137160-11-3
分子式:C20H21N3.HCl
分子量：339.86
溶解度:DMSO: 100 mM,Water: 50 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.

Reddy et al (1994) Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 37 260 PMID:8295213 |Schäbitz et al (2000) The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31 1709 PMID:10884477