A polypeptide antibiotic
货号:ajcx26510
CAS:22601-59-8
分子式:C66H103N17O16S
分子量：1422.7
溶解度:DMSO: slightly soluble,Methanol: slightly, sonicated
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Bacitracin A is a polypeptide antibiotic that has been found inB. licheniformisand the main active component of the bacitracin family of polypeptide antibiotics.¹It is active againstM. lysodeikticuswhen used at a concentration of 0.1 µM and forms a complex with divalent cations and the cell membrane component C55-isoprenyl pyrophosphate.²Bacitracin A is also active against the plant pathogenic bacteriaP. ananatiswith a median effective concentration (MEC) of 9.1 µg/ml.³It induces cell wall damage and cell leakage inP. ananatis.

1.Newton, G.G.F., and Abraham, E.P.Observations on the nature of bacitracin ABiochem. J.53(4)604-613(1953) 2.Storm, D.R., and Strominger, J.L.Complex formation between bacitracin peptides and isoprenyl pyrophosphates. The specificity of lipid-peptide interactionsJ. Biol. Chem.248(11)3940-3945(1973) 3.Jin, P., Tan, Z., Wang, H., et al.Antimicrobial effect of Bacillus licheniformis HN-5 bacitracin A on rice pathogen Pantoea ananatisBioControl66249-257(2020)