A mixture of PDMP isomers
货号:ajcx26278
CAS:80943-40-4
分子式:C23H38N2O3 • HCl
分子量：427
溶解度:DMF: 25 mg/mL,DMSO: 30 mg/mL,Ethanol: 50 mg/mL,Ethanol:PBS(pH 7.2) (1:5): 0.05 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DL-erythro-PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-erythro-(1S,2R)-PDMP and L-erythro-(1R,2S)-PDMP.^1,2It protects glucosylceramide (GlcCer) synthase from degradation and increases the level of ceramide in MDCK cells when used at a concentration of 40 µM.²Unlike DL-threo-PDMP, DL-erythro-PDMP does not inhibit GlcCer synthase, but it does inhibit UDP galactose:ceramide galactosyltransferase by 27% in mouse brain microsomes when used at a concentration of 100 µM.³It inhibits the growth of isolated rabbit skin fibroblasts when used at a concentration of 50 µM but is cytotoxic at concentrations higher than 50 µM.⁴[Matreya, LLC. Catalog No. 1755]

1.Vunnam, R.R., and Radin, N.S.Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brainChem. Phys. Lipids26(3)265-278(1980) 2.Abe, A., Radin, N.S., and Shayman, J.A.Induction of glucosylceramide synthase by synthase inhibitors and ceramideBiochim. Biophys. Acta.1299(3)333-341(1996) 3.Inokuchi, J.i., and Radin, N.S.Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetaseJ. Lipid Res.28(5)565-571(1987) 4.Uemura, K., Sugiyama, E., Tamai, C., et al.Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblastsJ. Biochem.108(4)525-530(1990)