An internal standard for the quantification of clofibric acid
货号:ajcx25152
CAS:1184991-14-7
分子式:C10H7ClD4O3
分子量：218.7
溶解度:Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Clofibric acid-d₄is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC₅₀= 50 µM in a transactivation assay) and the active metabolite of clofibrate .¹It is formed from clofibrate by tissue and serum esterases.²Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats.³It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 µg/L.⁴Clofibric acid has been found in wastewater effluent.⁵

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