An analog of taxol with antitumor properties
货号:ajcx24926
CAS:700367-34-6
分子式:C43H53NO14·XH2O
分子量：807.9
溶解度:DMF: 5 mg/ml,DMSO: 5 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 1.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC₅₀= 0.2 μM) and inhibits cell replication (IC₅₀= 0.13 μM).¹It has proven more effective than taxol in preventing the proliferation of cancer cells.^1,2Docetaxel has applications in breast cancer and hormone-refractory prostate cancer.^3,4This product is intended for research applications.

1.Bissery, M.C., Guenard, D., Gueritte-Voegelein, F., et al.Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogueCancer Research514845-4852(1991) 2.Pazdur, R., Kudelka, A.P., Kavanagh, J.J., et al.The taxoids: Paclitaxel (Taxolr) and docetaxel (Taxoterer)Cancer Treatment Reviews19351-386(1993) 3.Mahon, K.L., Henshall, S.M., Sutherland, R.L., et al.Pathways of chemotherapy resistance in castration-resistant prostate cancerEndocrine-Related Cancer18R103-R123(2011) 4.Yao, X., Hosenpud, J., Chitambar, C.R., et al.A phase II study of concurrent docetaxel, epirubicin and cyclophospha-mide as a neoadjuvant chemotherapy regimen in patients with locally advanced breast cancerJournal of Cancer3145-151(2012)